Controlled Protein Delivery Based on Enzyme-Responsive Nanocapsules
نویسندگان
چکیده
منابع مشابه
Redox-responsive nanocapsules for intracellular protein delivery.
Direct delivery of proteins to the cytosol of cells holds tremendous potential in biological and medical applications. Engineering vehicles for escorting proteins to the cytosol in a controlled release fashion has thus generated considerable interest. We report here the preparation of redox-responsive single-protein nanocapsules for intracellular protein delivery. Through in situ interfacial po...
متن کاملEndoprotease-mediated intracellular protein delivery using nanocapsules.
Proteins possess distinct intracellular roles allowing them to have vast therapeutic applications. However, due to poor cellular permeability and fragility of most proteins, intracellular delivery of native, active proteins is challenging. We describe a biomimetic protein delivery vehicle which is degradable upon the digestion by furin, a ubiquitous intracellular protease, to release encapsulat...
متن کاملPolymer-based nanocapsules for drug delivery.
A review of the state of knowledge on nanocapsules prepared from preformed polymers as active substances carriers is presented. This entails a general review of the different preparation methods: nanoprecipitation, emulsion-diffusion, double emulsification, emulsion-coacervation, polymer-coating and layer-by-layer, from the point of view of the methodological and mechanistic aspects involved, e...
متن کاملStimuli-Responsive Polymeric Systems for Controlled Protein and Peptide Delivery: Future Implications for Ocular Delivery.
Therapeutic proteins and peptides have become notable in the drug delivery arena for their compatibility with the human body as well as their high potency. However, their biocompatibility and high potency does not negate the existence of challenges resulting from physicochemical properties of proteins and peptides, including large size, short half-life, capability to provoke immune responses an...
متن کاملNano-food engineering: amylose-based nanocapsules as edible controlled delivery systems
Unbalanced western-style diet and a sedentary lifestyle are increasingly recognized as important contributors to the observed increase in obesity and chronic diseases in the western world. Supplementing foods with health promoting bioactive ingredients poses a major technological challenge since some of these constituents, like omega-3 poly-unsaturated fatty acids (PUFA), exhibit poor chemical ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Advanced Materials
سال: 2011
ISSN: 0935-9648
DOI: 10.1002/adma.201101771